Arizona Cardinals vs San Francisco 49ers

atCardinals at 49ers

Week 3

September 27 · 4:05 PM EDT

· SF -11.5 · O/U 46.5

The read

There's a playoff line running through this one: 49ers sit in a postseason spot, while Cardinals are on the outside chasing a crossover, so it means a little more to the club playing from behind. Momentum cuts both ways: ARI arrive coming off a loss, SF on a 1-game win streak.

What's at stake

Where a win or a loss leaves each side.

Where they standLast 5Last 5Record

Arizona Cardinals3rd in the NFC West, 1.5 backLWLLLL10-0Away

San Francisco 49ers2nd in the NFC West, 1 backWLLWLW10-0Home

Injury report

Who is unavailable, in each club’s own words to the league. A day-to-day designation still allows a start, so a name here is not always a scratch; an injured-list stint is.

Arizona Cardinals5 listed

James ConnerRB · is questionable. Back 2026-08-28.

Jeremiyah LoveRB · is questionable. Back 2026-09-13.

Trey BensonRB · is listed injured reserve. Back 2027-02-15.

Xavier WeaverWR · is listed injured reserve. Back 2027-02-15.

Carson BeckQB · is questionable. Back 2026-08-28.

San Francisco 49ers5 listed

Mike EvansWR · is questionable. Back 2026-09-10.

Robert JonesG · is questionable. Back 2026-09-10.

Kurtis RourkeQB · is questionable. Back 2026-09-10.

Upton StoutCB · is questionable. Back 2026-08-27.

Jacob CowingWR · is questionable. Back 2026-08-27.

Projected starting lineups

Each club's published depth chart, top of the order at every spot. A chart is not a game plan, and coaches confirm the actual card closer to kickoff.

Arizona CardinalsDepth chart

Offense11

Jacoby Brissett#76' 4"11 yr

Jeremiyah Love#46' 0"RookieQuestionable

Marvin Harrison Jr.#186' 3"3 yr

Michael Wilson#146' 2"4 yr

Kendrick Bourne#176' 1"10 yr

Trey McBride#856' 4"5 yr

Paris Johnson Jr.#706' 6"4 yr

Isaac Seumalo#736' 4"11 yr

Hjalte Froholdt#726' 5"8 yr

Isaiah Adams#746' 4"3 yr

Elijah Wilkinson#656' 6"10 yr

Defense11

LDE

Josh Sweat#106' 5"9 yr

LDT

Roy Lopez#516' 2"6 yr

RDT

Walter Nolen III#976' 4"2 yr

RDE

Darius Robinson#566' 5"3 yr

WLB

Cody Simon#06' 2"2 yr

MLB

Mack Wilson Sr.#16' 1"8 yr

SLB

Zaven Collins#256' 4"6 yr

LCB

Will Johnson#26' 2"2 yr

RCB

Denzel Burke#295' 11"2 yr

Budda Baker#35' 10"10 yr

Andrew Wingard#276' 0"8 yr

Special teams5

Chad Ryland#386' 0"4 yr

Blake Gillikin#126' 2"7 yrQuestionable

Casey Kreiter#596' 1"11 yr

Devin Duvernay#815' 11"6 yr

San Francisco 49ersDepth chart

Offense11

Brock Purdy#136' 1"5 yr

Christian McCaffrey#235' 11"10 yrQuestionable

Mike Evans#56' 5"13 yrQuestionable

Deebo Samuel Sr.#196' 0"8 yr

De'Zhaun Stribling#156' 2"RookieQuestionable

George Kittle#856' 4"10 yrQuestionable

Trent Williams#716' 5"17 yr

Robert Jones#656' 4"6 yrQuestionable

Jake Brendel#646' 4"9 yr

Dominick Puni#776' 5"3 yrQuestionable

Colton McKivitz#686' 6"7 yr

Defense11

LDE

C.J. West#996' 1"2 yr

Alfred Collins#956' 5"2 yr

RDE

Osa Odighizuwa#926' 2"6 yr

WLB

Nick Bosa#976' 4"8 yrQuestionable

LILB

Dre Greenlaw#576' 0"8 yr

RILB

Fred Warner#546' 3"9 yr

SLB

Mykel Williams#986' 5"2 yrOut

LCB

Deommodore Lenoir#25' 10"6 yr

RCB

Renardo Green#06' 0"3 yrQuestionable

Ji'Ayir Brown#275' 11"4 yr

Malik Mustapha#65' 10"3 yrQuestionable

Special teams5

Eddy Pineiro#185' 11"9 yr

Corliss Waitman#76' 2"4 yr

Jon Weeks#465' 10"17 yr

Isaac Guerendo#316' 0"3 yrOut

Jacob Cowing#65' 9"3 yrQuestionable

League standings

The full ladder, with both clubs marked.

AFC East

#ClubW-LPCTStreak

1Buffalo Bills2-01.000W2

2New England Patriots1-0.750W1

3New York Jets1-1.500W1

4Miami Dolphins0-2.000L2

AFC North

#ClubW-LPCTStreak

1Cincinnati Bengals2-01.000W2

2Baltimore Ravens2-01.000W2

3Pittsburgh Steelers1-1.500L1

4Cleveland Browns0-2.000L2

AFC South

#ClubW-LPCTStreak

1Tennessee Titans2-01.000W2

2Jacksonville Jaguars1-1.500L1

3Indianapolis Colts0-1.250L1

4Houston Texans0-2.000L2

AFC West

#ClubW-LPCTStreak

1Los Angeles Chargers1-1.500L1

2Las Vegas Raiders1-1.500W1

3Denver Broncos1-1.500L1

4Kansas City Chiefs0-2.000L2

NFC East

#ClubW-LPCTStreak

1Dallas Cowboys2-01.000W2

2Washington Commanders1-1.500L1

3New York Giants1-1.500W1

4Philadelphia Eagles0-2.000L2

NFC North

#ClubW-LPCTStreak

1Detroit Lions1-1.500W1

2Minnesota Vikings1-1.500L1

3Green Bay Packers1-1.500W1

4Chicago Bears1-1.500L1

NFC South

#ClubW-LPCTStreak

1Tampa Bay Buccaneers2-01.000W2

2Carolina Panthers2-1.667W1

3Atlanta Falcons1-1.500W1

4New Orleans Saints0-2.000L2

NFC West

#ClubW-LPCTStreak

1Los Angeles Rams2-01.000W2

2San Francisco 49ers1-1.500W1

3Arizona Cardinals1-2.333L1

4Seattle Seahawks0-2.000L2

Win probability

Arizona Cardinals

19%

San Francisco 49ers

81%

Cardinals at 49ers

Arizona

Cardinals

San Francisco

49ers

Post Game SummaryStat Savant

atCardinals at 49ers

Week 3

September 27 · 4:05 PM EDT

· SF -11.5 · O/U 46.5

The read

What's at stake

Where a win or a loss leaves each side.

Where they standLast 5Last 5Record

Arizona Cardinals3rd in the NFC West, 1.5 backLWLLLL10-0Away

San Francisco 49ers2nd in the NFC West, 1 backWLLWLW10-0Home

Injury report

Who is unavailable, in each club’s own words to the league. A day-to-day designation still allows a start, so a name here is not always a scratch; an injured-list stint is.

Arizona Cardinals5 listed

James ConnerRB · is questionable. Back 2026-08-28.

Jeremiyah LoveRB · is questionable. Back 2026-09-13.

Trey BensonRB · is listed injured reserve. Back 2027-02-15.

Xavier WeaverWR · is listed injured reserve. Back 2027-02-15.

Carson BeckQB · is questionable. Back 2026-08-28.

San Francisco 49ers5 listed

Mike EvansWR · is questionable. Back 2026-09-10.

Robert JonesG · is questionable. Back 2026-09-10.

Kurtis RourkeQB · is questionable. Back 2026-09-10.

Upton StoutCB · is questionable. Back 2026-08-27.

Jacob CowingWR · is questionable. Back 2026-08-27.

Projected starting lineups

Each club's published depth chart, top of the order at every spot. A chart is not a game plan, and coaches confirm the actual card closer to kickoff.

Arizona CardinalsDepth chart

Offense11

Jacoby Brissett#76' 4"11 yr

Jeremiyah Love#46' 0"RookieQuestionable

Marvin Harrison Jr.#186' 3"3 yr

Michael Wilson#146' 2"4 yr

Kendrick Bourne#176' 1"10 yr

Trey McBride#856' 4"5 yr

Paris Johnson Jr.#706' 6"4 yr

Isaac Seumalo#736' 4"11 yr

Hjalte Froholdt#726' 5"8 yr

Isaiah Adams#746' 4"3 yr

Elijah Wilkinson#656' 6"10 yr

Defense11

LDE

Josh Sweat#106' 5"9 yr

LDT

Roy Lopez#516' 2"6 yr

RDT

Walter Nolen III#976' 4"2 yr

RDE

Darius Robinson#566' 5"3 yr

WLB

Cody Simon#06' 2"2 yr

MLB

Mack Wilson Sr.#16' 1"8 yr

SLB

Zaven Collins#256' 4"6 yr

LCB

Will Johnson#26' 2"2 yr

RCB

Denzel Burke#295' 11"2 yr

Budda Baker#35' 10"10 yr

Andrew Wingard#276' 0"8 yr

Special teams5

Chad Ryland#386' 0"4 yr

Blake Gillikin#126' 2"7 yrQuestionable

Casey Kreiter#596' 1"11 yr

Devin Duvernay#815' 11"6 yr

San Francisco 49ersDepth chart

Offense11

Brock Purdy#136' 1"5 yr

Christian McCaffrey#235' 11"10 yrQuestionable

Mike Evans#56' 5"13 yrQuestionable

Deebo Samuel Sr.#196' 0"8 yr

De'Zhaun Stribling#156' 2"RookieQuestionable

George Kittle#856' 4"10 yrQuestionable

Trent Williams#716' 5"17 yr

Robert Jones#656' 4"6 yrQuestionable

Jake Brendel#646' 4"9 yr

Dominick Puni#776' 5"3 yrQuestionable

Colton McKivitz#686' 6"7 yr

Defense11

LDE

C.J. West#996' 1"2 yr

Alfred Collins#956' 5"2 yr

RDE

Osa Odighizuwa#926' 2"6 yr

WLB

Nick Bosa#976' 4"8 yrQuestionable

LILB

Dre Greenlaw#576' 0"8 yr

RILB

Fred Warner#546' 3"9 yr

SLB

Mykel Williams#986' 5"2 yrOut

LCB

Deommodore Lenoir#25' 10"6 yr

RCB

Renardo Green#06' 0"3 yrQuestionable

Ji'Ayir Brown#275' 11"4 yr

Malik Mustapha#65' 10"3 yrQuestionable

Special teams5

Eddy Pineiro#185' 11"9 yr

Corliss Waitman#76' 2"4 yr

Jon Weeks#465' 10"17 yr

Isaac Guerendo#316' 0"3 yrOut

Jacob Cowing#65' 9"3 yrQuestionable

League standings

The full ladder, with both clubs marked.

AFC East

#ClubW-LPCTStreak

1Buffalo Bills2-01.000W2

2New England Patriots1-0.750W1

3New York Jets1-1.500W1

4Miami Dolphins0-2.000L2

AFC North

#ClubW-LPCTStreak

1Cincinnati Bengals2-01.000W2

2Baltimore Ravens2-01.000W2

3Pittsburgh Steelers1-1.500L1

4Cleveland Browns0-2.000L2

AFC South

#ClubW-LPCTStreak

1Tennessee Titans2-01.000W2

2Jacksonville Jaguars1-1.500L1

3Indianapolis Colts0-1.250L1

4Houston Texans0-2.000L2

AFC West

#ClubW-LPCTStreak

1Los Angeles Chargers1-1.500L1

2Las Vegas Raiders1-1.500W1

3Denver Broncos1-1.500L1

4Kansas City Chiefs0-2.000L2

NFC East

#ClubW-LPCTStreak

1Dallas Cowboys2-01.000W2

2Washington Commanders1-1.500L1

3New York Giants1-1.500W1

4Philadelphia Eagles0-2.000L2

NFC North

#ClubW-LPCTStreak

1Detroit Lions1-1.500W1

2Minnesota Vikings1-1.500L1

3Green Bay Packers1-1.500W1

4Chicago Bears1-1.500L1

NFC South

#ClubW-LPCTStreak

1Tampa Bay Buccaneers2-01.000W2

2Carolina Panthers2-1.667W1

3Atlanta Falcons1-1.500W1

4New Orleans Saints0-2.000L2

NFC West

#ClubW-LPCTStreak

1Los Angeles Rams2-01.000W2

2San Francisco 49ers1-1.500W1

3Arizona Cardinals1-2.333L1

4Seattle Seahawks0-2.000L2

Win probability

Arizona Cardinals

19%

San Francisco 49ers

81%

Arizona Cardinals vs San Francisco 49ers — Sep 27, 2026

The read

What's at stake

Injury report

Projected starting lineups

League standings

Win probability

Arizona Cardinals vs San Francisco 49ers — Sep 27, 2026

The read

What's at stake

Injury report

Projected starting lineups

League standings

Win probability