Denver Broncos vs San Francisco 49ers

atBroncos at 49ers

Week 4

October 4 · 4:25 PM EDT

· SF -2.5 · O/U 46.5

The read

There's a playoff line running through this one: 49ers sit in a postseason spot, while Broncos are on the outside chasing a crossover, so it means a little more to the club playing from behind. Momentum cuts both ways: DEN arrive coming off a loss, SF on a 1-game win streak.

What's at stake

Where a win or a loss leaves each side.

Where they standLast 5Last 5Record

Denver Broncos3rd in the AFC WestLWLWWL10-0Away

San Francisco 49ers2nd in the NFC West, 1 backWLLWLW10-0Home

Injury report

Who is unavailable, in each club’s own words to the league. A day-to-day designation still allows a start, so a name here is not always a scratch; an injured-list stint is.

Denver Broncos5 listed

Riley MossCB · is questionable. Back 2026-08-28.

Levelle BaileyLB · is listed injured reserve. Back 2027-02-15.

Luke WattenbergCatcher · is questionable. Back 2026-08-28.

Matt HenningsenDE · is listed injured reserve. Back 2027-02-15.

Michael DeiterCatcher · is listed injured reserve. Back 2027-02-15.

San Francisco 49ers5 listed

Victor DimukejeDE · is listed injured reserve. Back 2027-02-15.

Mike EvansWR · is questionable. Back 2026-09-10.

Robert JonesG · is questionable. Back 2026-09-10.

Kurtis RourkeQB · is questionable. Back 2026-09-10.

Upton StoutCB · is questionable. Back 2026-08-27.

Projected starting lineups

Each club's published depth chart, top of the order at every spot. A chart is not a game plan, and coaches confirm the actual card closer to kickoff.

Denver BroncosDepth chart

Offense11

Bo Nix#106' 2"3 yr

J.K. Dobbins#275' 10"7 yr

Courtland Sutton#146' 4"9 yr

Jaylen Waddle#175' 10"6 yr

Troy Franklin#116' 3"3 yr

Evan Engram#16' 3"10 yr

Garett Bolles#726' 5"10 yr

Ben Powers#746' 4"8 yr

Luke Wattenberg#606' 5"5 yrQuestionable

Quinn Meinerz#776' 3"6 yr

Mike McGlinchey#696' 8"9 yr

Defense11

LDE

Malcolm Roach#976' 3"7 yr

D.J. Jones#936' 0"10 yr

RDE

Zach Allen#996' 5"8 yr

WLB

Jonathon Cooper#06' 4"6 yr

LILB

Alex Singleton#496' 2"8 yr

RILB

Justin Strnad#406' 3"7 yr

SLB

Nik Bonitto#156' 3"5 yr

LCB

Pat Surtain II#26' 2"6 yr

RCB

Riley Moss#216' 0"4 yrQuestionable

Talanoa Hufanga#96' 0"6 yr

Brandon Jones#226' 0"7 yr

Special teams5

Wil Lutz#35' 11"11 yr

Jeremy Crawshaw#166' 3"2 yr

Mitchell Fraboni#486' 2"5 yr

Marvin Mims Jr.#195' 11"4 yr

San Francisco 49ersDepth chart

Offense11

Brock Purdy#136' 1"5 yr

Christian McCaffrey#235' 11"10 yrQuestionable

Mike Evans#56' 5"13 yrQuestionable

Deebo Samuel Sr.#196' 0"8 yr

De'Zhaun Stribling#156' 2"RookieQuestionable

George Kittle#856' 4"10 yrQuestionable

Trent Williams#716' 5"17 yr

Robert Jones#656' 4"6 yrQuestionable

Jake Brendel#646' 4"9 yr

Dominick Puni#776' 5"3 yrQuestionable

Colton McKivitz#686' 6"7 yr

Defense11

LDE

C.J. West#996' 1"2 yr

Alfred Collins#956' 5"2 yr

RDE

Osa Odighizuwa#926' 2"6 yr

WLB

Nick Bosa#976' 4"8 yrQuestionable

LILB

Dre Greenlaw#576' 0"8 yr

RILB

Fred Warner#546' 3"9 yr

SLB

Mykel Williams#986' 5"2 yrOut

LCB

Deommodore Lenoir#25' 10"6 yr

RCB

Renardo Green#06' 0"3 yrQuestionable

Ji'Ayir Brown#275' 11"4 yr

Malik Mustapha#65' 10"3 yrQuestionable

Special teams5

Eddy Pineiro#185' 11"9 yr

Corliss Waitman#76' 2"4 yr

Jon Weeks#465' 10"17 yr

Isaac Guerendo#316' 0"3 yrOut

Jacob Cowing#65' 9"3 yrQuestionable

League standings

The full ladder, with both clubs marked.

AFC East

#ClubW-LPCTStreak

1Buffalo Bills2-01.000W2

2New England Patriots1-0.750W1

3New York Jets1-1.500W1

4Miami Dolphins0-2.000L2

AFC North

#ClubW-LPCTStreak

1Cincinnati Bengals2-01.000W2

2Baltimore Ravens2-01.000W2

3Pittsburgh Steelers1-1.500L1

4Cleveland Browns0-2.000L2

AFC South

#ClubW-LPCTStreak

1Tennessee Titans2-01.000W2

2Jacksonville Jaguars1-1.500L1

3Indianapolis Colts0-1.250L1

4Houston Texans0-2.000L2

AFC West

#ClubW-LPCTStreak

1Los Angeles Chargers1-1.500L1

2Las Vegas Raiders1-1.500W1

3Denver Broncos1-1.500L1

4Kansas City Chiefs0-2.000L2

NFC East

#ClubW-LPCTStreak

1Dallas Cowboys2-01.000W2

2Washington Commanders1-1.500L1

3New York Giants1-1.500W1

4Philadelphia Eagles0-2.000L2

NFC North

#ClubW-LPCTStreak

1Detroit Lions1-1.500W1

2Minnesota Vikings1-1.500L1

3Green Bay Packers1-1.500W1

4Chicago Bears1-1.500L1

NFC South

#ClubW-LPCTStreak

1Tampa Bay Buccaneers2-01.000W2

2Carolina Panthers2-1.667W1

3Atlanta Falcons1-1.500W1

4New Orleans Saints0-2.000L2

NFC West

#ClubW-LPCTStreak

1Los Angeles Rams2-01.000W2

2San Francisco 49ers1-1.500W1

3Arizona Cardinals1-2.333L1

4Seattle Seahawks0-2.000L2

Win probability

Denver Broncos

38%

San Francisco 49ers

62%

Broncos at 49ers

Denver

Broncos

San Francisco

49ers

Post Game SummaryStat Savant

atBroncos at 49ers

Week 4

October 4 · 4:25 PM EDT

· SF -2.5 · O/U 46.5

The read

What's at stake

Where a win or a loss leaves each side.

Where they standLast 5Last 5Record

Denver Broncos3rd in the AFC WestLWLWWL10-0Away

San Francisco 49ers2nd in the NFC West, 1 backWLLWLW10-0Home

Injury report

Who is unavailable, in each club’s own words to the league. A day-to-day designation still allows a start, so a name here is not always a scratch; an injured-list stint is.

Denver Broncos5 listed

Riley MossCB · is questionable. Back 2026-08-28.

Levelle BaileyLB · is listed injured reserve. Back 2027-02-15.

Luke WattenbergCatcher · is questionable. Back 2026-08-28.

Matt HenningsenDE · is listed injured reserve. Back 2027-02-15.

Michael DeiterCatcher · is listed injured reserve. Back 2027-02-15.

San Francisco 49ers5 listed

Victor DimukejeDE · is listed injured reserve. Back 2027-02-15.

Mike EvansWR · is questionable. Back 2026-09-10.

Robert JonesG · is questionable. Back 2026-09-10.

Kurtis RourkeQB · is questionable. Back 2026-09-10.

Upton StoutCB · is questionable. Back 2026-08-27.

Projected starting lineups

Each club's published depth chart, top of the order at every spot. A chart is not a game plan, and coaches confirm the actual card closer to kickoff.

Denver BroncosDepth chart

Offense11

Bo Nix#106' 2"3 yr

J.K. Dobbins#275' 10"7 yr

Courtland Sutton#146' 4"9 yr

Jaylen Waddle#175' 10"6 yr

Troy Franklin#116' 3"3 yr

Evan Engram#16' 3"10 yr

Garett Bolles#726' 5"10 yr

Ben Powers#746' 4"8 yr

Luke Wattenberg#606' 5"5 yrQuestionable

Quinn Meinerz#776' 3"6 yr

Mike McGlinchey#696' 8"9 yr

Defense11

LDE

Malcolm Roach#976' 3"7 yr

D.J. Jones#936' 0"10 yr

RDE

Zach Allen#996' 5"8 yr

WLB

Jonathon Cooper#06' 4"6 yr

LILB

Alex Singleton#496' 2"8 yr

RILB

Justin Strnad#406' 3"7 yr

SLB

Nik Bonitto#156' 3"5 yr

LCB

Pat Surtain II#26' 2"6 yr

RCB

Riley Moss#216' 0"4 yrQuestionable

Talanoa Hufanga#96' 0"6 yr

Brandon Jones#226' 0"7 yr

Special teams5

Wil Lutz#35' 11"11 yr

Jeremy Crawshaw#166' 3"2 yr

Mitchell Fraboni#486' 2"5 yr

Marvin Mims Jr.#195' 11"4 yr

San Francisco 49ersDepth chart

Offense11

Brock Purdy#136' 1"5 yr

Christian McCaffrey#235' 11"10 yrQuestionable

Mike Evans#56' 5"13 yrQuestionable

Deebo Samuel Sr.#196' 0"8 yr

De'Zhaun Stribling#156' 2"RookieQuestionable

George Kittle#856' 4"10 yrQuestionable

Trent Williams#716' 5"17 yr

Robert Jones#656' 4"6 yrQuestionable

Jake Brendel#646' 4"9 yr

Dominick Puni#776' 5"3 yrQuestionable

Colton McKivitz#686' 6"7 yr

Defense11

LDE

C.J. West#996' 1"2 yr

Alfred Collins#956' 5"2 yr

RDE

Osa Odighizuwa#926' 2"6 yr

WLB

Nick Bosa#976' 4"8 yrQuestionable

LILB

Dre Greenlaw#576' 0"8 yr

RILB

Fred Warner#546' 3"9 yr

SLB

Mykel Williams#986' 5"2 yrOut

LCB

Deommodore Lenoir#25' 10"6 yr

RCB

Renardo Green#06' 0"3 yrQuestionable

Ji'Ayir Brown#275' 11"4 yr

Malik Mustapha#65' 10"3 yrQuestionable

Special teams5

Eddy Pineiro#185' 11"9 yr

Corliss Waitman#76' 2"4 yr

Jon Weeks#465' 10"17 yr

Isaac Guerendo#316' 0"3 yrOut

Jacob Cowing#65' 9"3 yrQuestionable

League standings

The full ladder, with both clubs marked.

AFC East

#ClubW-LPCTStreak

1Buffalo Bills2-01.000W2

2New England Patriots1-0.750W1

3New York Jets1-1.500W1

4Miami Dolphins0-2.000L2

AFC North

#ClubW-LPCTStreak

1Cincinnati Bengals2-01.000W2

2Baltimore Ravens2-01.000W2

3Pittsburgh Steelers1-1.500L1

4Cleveland Browns0-2.000L2

AFC South

#ClubW-LPCTStreak

1Tennessee Titans2-01.000W2

2Jacksonville Jaguars1-1.500L1

3Indianapolis Colts0-1.250L1

4Houston Texans0-2.000L2

AFC West

#ClubW-LPCTStreak

1Los Angeles Chargers1-1.500L1

2Las Vegas Raiders1-1.500W1

3Denver Broncos1-1.500L1

4Kansas City Chiefs0-2.000L2

NFC East

#ClubW-LPCTStreak

1Dallas Cowboys2-01.000W2

2Washington Commanders1-1.500L1

3New York Giants1-1.500W1

4Philadelphia Eagles0-2.000L2

NFC North

#ClubW-LPCTStreak

1Detroit Lions1-1.500W1

2Minnesota Vikings1-1.500L1

3Green Bay Packers1-1.500W1

4Chicago Bears1-1.500L1

NFC South

#ClubW-LPCTStreak

1Tampa Bay Buccaneers2-01.000W2

2Carolina Panthers2-1.667W1

3Atlanta Falcons1-1.500W1

4New Orleans Saints0-2.000L2

NFC West

#ClubW-LPCTStreak

1Los Angeles Rams2-01.000W2

2San Francisco 49ers1-1.500W1

3Arizona Cardinals1-2.333L1

4Seattle Seahawks0-2.000L2

Win probability

Denver Broncos

38%

San Francisco 49ers

62%

Denver Broncos vs San Francisco 49ers — Oct 4, 2026

The read

What's at stake

Injury report

Projected starting lineups

League standings

Win probability

Denver Broncos vs San Francisco 49ers — Oct 4, 2026

The read

What's at stake

Injury report

Projected starting lineups

League standings

Win probability