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Stat SavantPremium issuesMy teams

Louisville Cardinals vs Syracuse Orange Prediction & Odds, Oct 17, 2026

FBS · 7:30 PM EDT · Sat, Oct 17, 2026 · ACC Network
JMA Wireless DomeJMA Wireless Dome · Syracuse, NY
Preview
Moneyline
Win prob.
Louisville Cardinals3-3
−530
45%
Syracuse Orange2-3
+390
55%
Total 55.5
Box score and highlights appear here at kickoff.

Saturday, 7:30 PM ET on ACC Network. Louisville by 11.5.

Syracuse hosts Louisville on Saturday, Oct 17, at JMA Wireless Dome. Kickoff is 7:30 PM ET (6:30 CT, 5:30 MT, 4:30 PT) on ACC Network. Louisville is a 11.5-point favorite, and the line gives them a 80% chance to win.

How we get these numbers

How to watch

Matchup
Louisville atSyracuse
Kickoff
Sat, Oct 17 · 7:30 PM ET · 6:30 CT · 5:30 MT · 4:30 PT
TV
ACC Network
Where
JMA Wireless Dome, Syracuse, NY
Add Syracuse to your calendar

Cardinals at Orange

Louisville at Syracuse.

What decides it

Louisville visits Syracuse at JMA Wireless Dome, kickoff 7:30 PM ET. Louisville comes in 3-3, eleventh in the Atlantic Coast Conference; Syracuse 2-3, sixteenth in the Atlantic Coast Conference.

Questions

What channel is the Louisville vs Syracuse game on?

ACC Network, Saturday at 7:30 PM ET.

What time is the Louisville vs Syracuse game?

7:30 PM ET on Saturday, Oct 17, which is 4:30 PT.

Who is favored, Louisville or Syracuse?

Louisville, by 11.5 points. The line gives them a 80% chance to win.

The line
Now
Moneyline
SYR +390 · LOU −530
Spread
SYR +11.5
Total
55.5
Moneyline opened LOU −450, now −530. Total opened 54.5, now 55.5.
Atlantic Coast Conference
W
L
PCT
Hurricanes
5
0
1.000
Demon Deacons
5
1
.833
Panthers
5
1
.833
Mustangs
4
1
.800
Blue Devils
4
1
.800
Cavaliers
4
2
.667
Hokies
4
2
.667
Tigers
3
2
.600
Tar Heels
3
2
.600
Golden Bears
3
3
.500
Cardinals
3
3
.500
Seminoles
3
3
.500
Wolfpack
3
3
.500
Yellow Jackets
2
3
.400
Eagles
2
3
.400
Orange
2
3
.400
Cardinal
2
4
.333

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Game emails · free

Your teams, before and after every game.

A preview two hours before the start and the box score minutes after the final. Free, and every email has its own off switch.

Leagues
NFLCollege footballMLBNBANHLWNBACollege basketball
Today’s games
Standings & playoffs
Playoff pictureCFP pictureCFB rankingsCFB standingsCBB rankingsCBB preview 2026-27CBB transfer portalNFL scheduleCFB scheduleNFL draft orderSchedule strengthNFL rivalries
Most followed
Dallas CowboysKansas City ChiefsNew York YankeesBuffalo BillsDetroit LionsChicago BearsPittsburgh SteelersGreen Bay PackersNew York GiantsChicago CubsBoston Red SoxNotre Dame
Fantasy tools
Start/sit rankingsLineup checkWho’s playing tonightTrade analyzerWaiver wireYour Sleeper leagueDefense vs positionFantasy playoff scheduleNFL bye weeksNHL schedule gridNBA schedule gridHockey streamers
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Highlights
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Fantasy tools+−
Start/sit rankingsLineup checkWho’s playing tonightTrade analyzerWaiver wireYour Sleeper leagueDefense vs positionFantasy playoff scheduleNFL bye weeksNHL schedule gridNBA schedule gridHockey streamers
Betting tools & picks+−
Odds converterParlay calculatorHedge calculatorExpected valueBet size (Kelly)Teasers, round robinsLine movementClosing line valuePrediction marketsNFL picksCollege football picks
Standings & playoffs+−
Playoff pictureCFP pictureCFB rankingsCFB standingsCBB rankingsCBB preview 2026-27CBB transfer portalNFL scheduleCFB scheduleNFL draft orderSchedule strength
Leagues+−
NFLCollege footballMLBNBANHLWNBACollege basketballToday’s games
Most followed+−
Dallas CowboysKansas City ChiefsNew York YankeesBuffalo BillsDetroit LionsChicago BearsPittsburgh SteelersGreen Bay PackersNew York GiantsChicago CubsBoston Red Sox
Read+−
Top plays last nightPlayer highlightsMLB walk-offsNews WireStat SavantBest BetsNFL preview 2026College football 2026Premium issuesBox Scores newsletterHow it worksHow we get our numbers
Highlights+−
Major League planInvite friendsPrivacyTermsLog in
A Mainmarket brand · 135 York St, Brooklyn, NY 11201 · Not affiliated with any league or team
Betting tools are for information. 21+. Gambling problem? Call 1-800-GAMBLER.

Scores, schedules, rosters and statistics come from public sports data feeds and are for information only. Odds, projections and win probabilities are for entertainment only and are not betting advice. Team names and marks belong to their owners and identify the clubs we cover. © 2026 MainMarket.com. All rights reserved.

MLB picks
NHL picks
NFL rivalries
Notre Dame

Best odds for Cardinals vs Orange

Every line on Best Bets
Cardinals −525 at Fanatics
$1.66 more on a winning $100 than DraftKings (−575)
Orange +425 at DraftKings
$65 more on a winning $100 than BetRivers (+360)

Moneyline, from the books we track at the last odds sync. Prices, not picks. 21+, where legal.