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San Francisco 49ers vs Los Angeles Rams — Sep 10, 2026

September 10 · 8:35 PM EDT
LAR -3.5 · O/U 48.5

What to look for

Momentum cuts both ways: SF arrive on a 2-game win streak, LAR winners of 3 straight. Where the market sits: the books make Rams a 3.5-point favorite, the no-vig price implies LAR at 64%, with the total set at 48.5. Our model lands in the same neighborhood.

Last five games

Each side's most recent results, newest first, with the score and who they played. These reach back into last season where a club has not played five yet, which is why every row carries its date.

San Francisco 49ers
  • 08/28/26W18-12atRaiders
  • 08/21/26W41-17atChargers
  • 08/14/26L13-19vsTitans
  • 01/04/26L3-13vsSeahawks
  • 12/29/25W42-38vsBears
Los Angeles Rams
  • 08/28/26W20-18atChargers
  • 08/22/26W34-0vsSaints
  • 08/15/26W20-12atChiefs
  • 01/04/26W37-20vsCardinals
  • 12/30/25L24-27atFalcons

Projected starting lineups

Each club's published depth chart, top of the order at every spot. A chart is not a game plan, and coaches confirm the actual card closer to kickoff.

San Francisco 49ersDepth chart
Offense11
QBBrock Purdy#136' 1"5 yr
RBChristian McCaffrey#235' 11"10 yrQuestionable
WRMike Evans#56' 5"13 yrQuestionable
WRDeebo Samuel Sr.#196' 0"8 yr
WRDe'Zhaun Stribling#156' 2"RookieQuestionable
TEGeorge Kittle#856' 4"10 yrQuestionable
LTTrent Williams#716' 5"17 yr
LGConnor Colby#756' 5"2 yr
CJake Brendel#646' 4"9 yr
RGDominick Puni#776' 5"3 yrQuestionable
RTColton McKivitz#686' 6"7 yr
Defense11
LDEC.J. West#996' 1"2 yr
NTAlfred Collins#956' 5"2 yr
RDEOsa Odighizuwa#926' 2"6 yr
WLBNick Bosa#976' 4"8 yrQuestionable
LILBDre Greenlaw#576' 0"8 yr
RILBFred Warner#546' 3"9 yr
SLBKeion White#566' 5"4 yrQuestionable
LCBRenardo Green#06' 0"3 yrQuestionable
RCBDeommodore Lenoir#25' 10"6 yr
SSMalik Mustapha#65' 10"3 yrQuestionable
FSJi'Ayir Brown#275' 11"4 yr
Special teams4
KEddy Pineiro#185' 11"9 yr
PCorliss Waitman#76' 2"4 yr
KRDeebo Samuel Sr.#196' 0"8 yr
PRJacob Cowing#65' 9"3 yrQuestionable
Los Angeles RamsDepth chart
Offense11
QBMatthew Stafford#96' 3"18 yr
RBKyren Williams#235' 9"5 yr
WRPuka Nacua#126' 2"4 yrQuestionable
WRDavante Adams#176' 1"13 yr
WRJordan Whittington#886' 1"3 yr
TEColby Parkinson#846' 7"7 yr
LTAlaric Jackson#776' 7"6 yrQuestionable
LGSteve Avila#736' 3"4 yr
CColeman Shelton#656' 5"8 yr
RGKevin Dotson#696' 4"7 yr
RTWarren McClendon Jr.#716' 4"4 yr
Defense11
LDEKobie Turner#916' 2"4 yrQuestionable
NTPoona Ford#975' 11"9 yr
RDEAaron Donald#996' 1"10 yr
WLBByron Young#06' 2"4 yr
LILBNate Landman#536' 3"5 yr
RILBOmar Speights#486' 1"3 yr
SLBMyles Garrett#956' 4"10 yrQuestionable
LCBJaylen Watson#356' 2"5 yr
RCBTrent McDuffie#225' 11"5 yr
SSKamren Kinchens#56' 0"3 yr
FSKam Curl#36' 2"7 yr
Special teams5
KHarrison Mevis#926' 0"2 yr
PEthan Evans#426' 3"4 yr
LSJoe Cardona#496' 2"12 yr
KRJordan Whittington#886' 1"3 yr
PRXavier Smith#195' 9"3 yr

Game odds and betting

SFLARMoneyline+160-192Spread+3.5-108-3.5-112TotalO 48.5-105U 48.5-115

What the market says

Favourite
LAR 64%
Spread
LAR -3.5
Total points
48.5

The favourite's chance is de-vigged: the two sides of a price add up to more than a whole, and that excess is the book's fee rather than anyone's opinion, 4.4% on this game.

Injury report

Los Angeles Rams
Alex JohnsonCB · back Feb 15Injured Reserve
Myles GarrettDE · back Sep 10Questionable
Puka NacuaWR · back Sep 10Questionable
Justin DedichG · back Oct 12Injured Reserve
Keagen TrostOT · back Oct 12Injured Reserve
San Francisco 49ers
Sam OkuayinonuDT · back Sep 10Questionable
Kyle JuszczykFB · back Sep 10Questionable
Nick BosaDE · back Sep 10Questionable
Mike EvansWR · back Sep 10Questionable
George KittleTE · back Sep 10Questionable

A day-to-day designation still allows a start, so a name here is not always a scratch; an injured-list stint is.

Standings

NFC West
#ClubW-L-DStreak
1Los Angeles Rams3-0-0W3
2San Francisco 49ers2-1-0W2
3Arizona Cardinals1-3-0L2
4Seattle Seahawks0-2-1-
Highlight
Teams & LeaguesPremium ContentNews WireBox ScoresNewsletters

Highlights is an email-first sports service: you follow the teams you care about, and we send the previews, recaps, box scores and news that belong to them. No app to install, no feed to scroll, and every email is free to start and takes one click to stop.

Scores, schedules, rosters, and statistics are aggregated from public sports data feeds and are provided for informational purposes only. Odds, projections, and win probabilities are for entertainment only and are not betting advice. Team names and marks belong to their respective owners and are used to identify the clubs we cover.

© 2026 MainMarket.com. All rights reserved.

Terms of UsePrivacy Policy